Rebel Wilson made her debut in the Australian comedy television series ‘Pizza’ in 2003. She played the role of ‘Toula’ and remained a part of the show until it went off-air in 2007. The series also inspired the 2003 Paul Fenech-directed Australian comedy film ‘Fat Pizza’ which marked the official big-screen debut of Wilson. The film received a positive response from critics. In 2007, she appeared in the American superhero film ‘Ghost Rider’ directed by Mark Steven Johnson. Even though the film was largely panned by critics, it turned out to be a commercial success, grossing over $228.7 million on a budget of $110 million. She next starred as ‘Brynn’ in the 2011 American comedy film ‘Bridesmaids’ directed by Paul Feig. The film earned praise from critics and was a box office success. In 2012, she voiced ‘Raz’ in the American computer-animated adventure comedy film ‘Ice Age: Continental Drift’ directed by Steve Martino and Michael Thurmeier. The film, despite receiving mixed reviews from critics, was a massive commercial success and grossed over $877.2 million on a $95 million budget. That same year, she also portrayed Patricia "Fat Amy" Hobart in the Jason Moore-directed American musical comedy film ‘Pitch Perfect.’ Wilson also received 2 ‘MTV Movie Awards’ along with a ‘Teen Choice Award’ for her performance in the film.
She next appeared in films like ‘Pain & Gain’ (2013), ‘Night at the Museum: Secret of the Tomb’ (2014), ‘Pitch Perfect 2’ (2015), ‘Kung Fu Panda 3’ (2016), ‘How to Be Single’ (2016), ‘Grimsby’ (2016), ‘Pitch Perfect 3’ (2017), ‘Isn't It Romantic’ (2019), ‘The Hustle’ (2019), and ‘Cats’ (2019). She was last seen in the Episode: "In The Hot Seat: Rebel Wilson & Amanda Peet" of the international television game show ‘Who Wants to Be a Millionaire?’ in 2021. She is all set to appear in the upcoming American comedy film ‘Senior Year’ where she will portray Stephanie Conway.