Rosie Perez made her debut in the 1989 American comedy-drama film ‘Do the Right Thing’ where she played the role of ‘Tina.’ The film opened to critical acclaim and was a major box office success, grossing over $37.3 million on a budget of $6 million. The following year, she became a part of the American sketch comedy television series ‘In Living Color’ created by Keenen Ivory Wayans and Damon Wayans. She received 3 ‘Emmy Award’ nominations and remained a part of the series until 1993. Around the same time, Perez also starred in films like ‘Night on Earth’ (1991), ‘White Men Can't Jump’ (1992), and ‘Untamed Heart’ (1993). In 1993, she received the ‘Academy Award’ nomination for her portrayal of ‘Carla Rodrigo’ in the American drama film ‘Fearless’ directed by Peter Weir. The film received positive reviews from critics. The following year, Perez appeared in the American romantic comedy-drama film ‘It Could Happen to You’ where she played the role of Andrew Bergman. The film opened to mostly positive reviews and was a commercial success, earning over $47.7 million on a budget of $20 million.
She next appeared in films like ‘A Brother's Kiss’ (1997), ‘Perdita Durango’ (1997), ‘The 24 Hour Woman’ (1999), ‘The Road to El Dorado’ (2000), ‘Human Nature’ (2001), ‘Lackawanna Blues’ (2005), ‘Home’ (2006), ‘Just Like the Son’ (2006), ‘The Take’ (2007), and ‘Pineapple Express’ (2008). In 2010, she was seen in the American buddy cop action comedy film ‘The Other Guys’ directed by Adam McKay. The film was well-received by critics and grossed over $170.9 million on a budget of $85–100 million. In 2012, she starred as ‘Ms. Baker’ in the American independent comedy film ‘Small Apartments’ directed by Jonas Åkerlund. The film saw its premiere at the South by Southwest Film Festival and received mixed to positive reviews from critics. That same year, she also appeared in the American drama film ‘Won't Back Down’ where she played the role of ‘Brenna Harper.’ The film saw mixed reviews upon release.
Perez continued to star in films like ‘The Counselor’ (2013), ‘Gods Behaving Badly’ (2013), ‘The Hero of Color City’ (2014), ‘Pitch Perfect 2’ (2015), ‘Puerto Ricans in Paris’ (2015), ‘Active Adults’ (2017), ‘The Dead Don't Die’ (2019), ‘Inside the Rain’ (2019), ‘Birds of Prey’ (2020), and ‘Have a Good Trip: Adventures in Psychedelics’ (2020). She was last seen in the 2021 adventure comedy film ‘Clifford the Big Red Dog’ directed by Walt Becker. The film opened to a mixed reception and gained an approval rating of 57% on Rotten Tomatoes.