Isaac Liev Schreiber first appeared in the dark-comedy āMixed Nutsā (1994), followed by small roles in indie-films and TV-movies.
Schreiber got noticed as āCotton Wearyā in the āScreamā (1996) trilogy, which fetched him a role in āRKO 281ā (1999) earning him nominations. He essayed supporting roles in āRansomā (1996), āThe Hurricaneā (1999), andĀ āHamletā (2000).
Schreiber featured in āKate & Leopoldā (2001), and the spy-thriller āThe Sum of All Fearsā (2002), followed by major roles in āThe Manchurian Candidateā (2004), āThe Omenā remake (2006).
Schreiber has provided narration for several documentaries, including āUnity,ā āAmerican Experience,ā āNova.āĀ
He was the writer-director of the comedy-drama āEverything is Illuminatedā (2005). His notable films include āDefianceā (2008), āX-Men Origins: Wolverineā (2009), āSpotlightā (2015), āGoon: Last of the Enforcersā (2017).
The accomplished stage-actor portrayed title roles in āHamletā (1999), āHenry Vā (2003), and āMacbethā (2006). After starring in the acclaimed play āThe Mercy Seatā (2002) he garnered accolades for Broadwayās āGlengarry Glen Rossā (2005), āTalk Radioā (2007), and āA View from the Bridgeā (2010).
Schreiber voiced āMy Little Ponyā (2017), āIsle of Dogsā (2018), and āSpider-Man: Into the Spider-Verseā (2018). He was producer-star of the drama-film āHuman Capitalā (2019).