Mary-Louise Parker made her screen debut in the 1988 American made-for-television historical drama war film ‘Too Young the Hero’ directed by Buzz Kulik. In 1989, she made her silver screen debut in the John David Coles-directed American film ‘Signs of Life.’ Following her debut, she went on to star in films such as ‘Fried Green Tomatoes’ (1991), ‘Grand Canyon’ (1991), ‘Mr. Wonderful’ (1993), ‘Naked in New York’ (1993), ‘Bullets Over Broadway’ (1994), ‘The Client’ (1994), and ‘Reckless’ (1995). In 1995, she starred as ‘Robin Nickerson’ in the American comedy-drama film ‘Boys on the Side’ directed by Herbert Ross. The film was warmly received by critics and grossed over $47.4 million on a budget of $21 million. She was next seen in films like ‘The Portrait of a Lady’ (1996), ‘Murder in Mind’ (1997), ‘The Maker’ (1997), ‘Goodbye Lover’ (1998), ‘Let the Devil Wear Black’ (1999), and ‘The Five Senses’ (1999). In 2001, she became a part of the American serial political drama television series ‘The West Wing’ created by Aaron Sorkin. She played the role of ‘Amy Gardner’ and remained on the show until 2006. She continued to star in television films and series like ‘Master Spy: The Robert Hanssen Story’ (2002), ‘Angels in America’ (2003), ‘Miracle Run’ (2004), and ‘Vinegar Hill’ (2005).Â
In 2005, she starred as ‘Nancy Botwin’ in the American dark comedy-drama television series ‘Weeds’ created by Jenji Kohan. The series ran for 8 seasons and aired its final episode in 2012. Parker also became a recipient of the ‘Golden Globe Award’ for her performance in the series. She next starred in television films and shows such as ‘The Robber Bride’ (2007), ‘The Blacklist’ (2014), ‘When We Rise’ (2017), ‘Billions’ (2017), and ‘Mr. Mercedes’ (2017). Parker was last seen in the 2021 American six-episode drama series ‘Colin in Black & White’ where she played the role of ‘Teresa Kaepernick.’