Cicely Tyson made her screen debut in the 1956 Harold Young-directed film, ‘Carib Gold’ where she made an uncredited appearance as ‘Dottie.’ She continued to make uncredited cameos in films like ‘Odds Against Tomorrow’ (1959), ‘The Last Angry Man’ (1959), and ‘Who Was That Lady?’ (1960). In 1963, she joined the cast of the American drama series ‘East Side West Side’ as ‘Jane Foster.’ The series was canceled after one season in 1964. She next appeared in television series and shows like ‘Slattery's People’ (1965), ‘I Spy’ (1965-1966), and ‘Guiding Light’ (1966). In 1966, she starred as ‘Claudia Ferguson’ in the American drama musical film ‘A Man Called Adam’ directed by Leo Penn. The film holds a 38% approval score on Rotten Tomatoes. The following year, she played the role of ‘Marie Therese’ in the Peter Glenville-directed American political drama film ‘The Comedians.’ The film received a lukewarm response from critics and earned a 27% approval rating on Rotten Tomatoes. She next starred as ‘Portia Copeland’ in the 1968 American film ‘The Heart Is a Lonely Hunter’ directed by Thomas C. Ryan. The film was inspired by Carson McCullers’ 1940 novel of the same name and grossed over $1.1 million at the box office.
Tyson received an ‘Academy Award’ nomination for her portrayal of ‘Rebecca Morgan’ in the 1972 American period drama film ‘Sounder’ directed by Martin Ritt. The film saw critical acclaim upon release and was a box office success, grossing over $16.9 million on a budget of $1.9 million. It was also selected for preservation in the United States National Film Registry in 2021. She next starred in films like ‘The Blue Bird’ (1976), ‘The River Niger’ (1976), ‘A Hero Ain't Nothin' but a Sandwich’ (1978), ‘The Concorde ... Airport '79’ (1979), ‘Bustin' Loose’ (1981), ‘Fried Green Tomatoes’ (1991), ‘Hoodlum’ (1997), ‘The Double Dutch Divas!’ (2001), and ‘Because of Winn-Dixie’ (2005). In 2005, she portrayed ‘Myrtle’ in the Darren Grant-directed American romantic comedy-drama film ‘Diary of a Mad Black Woman.’ Even though the film was panned by critics, it performed well at the box office and grossed over $50.7 million on a budget of $5.5 million. She was next seen in films such as ‘Madea's Family Reunion’ (2006), ‘Idlewild’ (2006), ‘Rwanda Rising’ (2007), ‘Up from the Bottoms: The Search for the American Dream’ (2009), ‘Why Did I Get Married Too?’ (2010), ‘The Help’ (2011), ‘Alex Cross’ (2012), ‘The Haunting in Connecticut 2: Ghosts of Georgia’ (2013), ‘Showing Roots’ (2016), and ‘Last Flag Flying’ (2017). Tyson last appeared in the 2020 American thriller film ‘A Fall from Grace’ directed by Tyler Perry. The film has a 16% approval rating on Rotten Tomatoes.