Mary Steenburgen made her screen debut in the 1978 American Western-comedy film ‘Goin' South’ directed by Jack Nicholson. The film received mixed to positive reviews from critics. The following year, she starred as ‘Amy Robbins’ in the Nicholas Meyer-directed American science fiction film ‘Time After Time.’ The film saw mostly positive reviews upon release. In 1980, she portrayed ‘Lynda West Dummar’ in the American comedy-drama film ‘Melvin and Howard’ directed by Jonathan Demme. The film opened to critical acclaim and sits on a 91% approval score on Rotten Tomatoes. Steenburgen also won several awards, including the ‘Golden Globe Award’ and the ‘Academy Award,’ for her performance in the film. She went on to star in films like ‘Ragtime’ (1981), ‘A Midsummer Night's Sex Comedy’ (1982), ‘Cross Creek’ (1983), ‘One Magic Christmas’ (1985), ‘Dead of Winter’ (1987), ‘End of the Line’ (1987), ‘Miss Firecracker’ (1989), ‘Back to the Future Part III’ (1990), ‘The Butcher's Wife’ (1991), and ‘What's Eating Gilbert Grape’ (1993). In 1993, she starred as ‘Belinda Conine’ in the American legal drama film ‘Philadelphia’ directed by Jonathan Demme. The film received mostly positive reviews from critics and was a major box office success, grossing over $206.7 million on a budget of $26 million.
She continued to star in films like ‘Clifford’ (1994), ‘My Family’ (1995), ‘Powder’ (1995), ‘Nixon’ (1995), ‘Nobody's Baby’ (2001), ‘Life as a House’ (2001), ‘Sunshine State’ (2002), ‘Wish You Were Dead’ (2002), ‘Hope Springs’ (2003), and ‘Casa de los Babys’ (2003). She portrayed ‘Emily Hobbs’ in the 2003 American Christmas comedy film ‘Elf’ directed by Jon Favreau. The film was lauded by critics and did impressive business at the box office, grossing over $225.1 million on a $33 million budget. She next starred in films like ‘Marilyn Hotchkiss' Ballroom Dancing & Charm School’ (2005), ‘The Dead Girl’ (2006), ‘Elvis and Anabelle’ (2007), ‘The Brave One’ (2007), ‘Step Brothers’ (2008), ‘In the Electric Mist’ (2009), ‘The Proposal’ (2009), ‘Dirty Girl’ (2010), ‘The Help’ (2011), ‘Last Vegas’ (2013), ‘Brahmin Bulls’ (2013), ‘Song One’ (2014), ‘A Walk in the Woods’ (2015), ‘Dean’ (2016), ‘The Discovery’ (2017), ‘Book Club’ (2018), ‘Flannery’ (2019), and ‘Happiest Season’ (2020). She was last seen in the 2021 American neo-noir psychological thriller film ‘Nightmare Alley’ directed by Guillermo del Toro. While the film opened to positive reviews, it failed to perform at the box office.