Crispin Glover first appeared in the 1981 television pilot episode, ‘The Best of Times.’ In 1983, he made his silver screen debut in the American sex comedy film ‘My Tutor’ directed by George Bowers. The following year, he starred as ‘Gatsby Boy’ in the American drama film ‘Racing with the Moon’ directed by Richard Benjamin. The film received a 60% approval rating on Rotten Tomatoes. That same year, he also played the role of ‘Jimmy Mortimer’ in the Joseph Zito-directed American slasher film ‘Friday the 13th: The Final Chapter.’ While the film was panned by critics, it performed well at the box office and grossed over $33 million on a $2.6 million budget. In 1985, he portrayed George McFly in the American science fiction film ‘Back to the Future’ directed by Robert Zemeckis. The film received mostly positive reviews from critics and was a phenomenal commercial success, grossing over $388.8 million on a $19 million budget. Back to the Future also came to be regarded as one of the greatest films of all time. He continued to star in films like ‘At Close Range’ (1986), ‘Twister’ (1989), ‘Where the Heart Is’ (1990), ‘The Doors’ (1991), ‘Even Cowgirls Get the Blues’ (1993), ‘What's Eating Gilbert Grape’ (1993), ‘Chasers’ (1994), and ‘Dead Man’ (1995).
In 1996, he starred as ‘Arlo’ in the American biographical drama film ‘The People vs. Larry Flynt’ directed by Miloš Forman. The film was widely praised by critics but failed to garner success at the box office. He next appeared in the 2000 Neil LaBute-directed American black comedy film ‘Nurse Betty.’ The film earned praise from critics and was a commercial success. He next starred in films like ‘Bartleby’ (2001), ‘Crime and Punishment’ (2002), ‘Like Mike’ (2002), ‘Willard’ (2003), ‘Charlie's Angels: Full Throttle’ (2003), and ‘Incident at Loch Ness’ (2004). In 2005, he produced, wrote, and directed the American surrealist film ‘What Is It?’ The film received a mixed response from critics. He was next seen in films like ‘Simon Says’ (2006), ‘Epic Movie’ (2007), ‘Beowulf’ (2007), ‘Open Season 2’ (2008), ‘The Donner Party’ (2009), ‘Alice in Wonderland’ (2010), ‘Open Season 3’ (2010), ‘Freaky Deaky’ (2012), ‘The Bag Man’ (2014), ‘Aimy in a Cage’ (2015), ‘The Con is On’ (2018), and ‘Lucky Day’ (2019). He was last seen in the 2020 American horror slasher film ‘Smiley Face Killers’ directed by Tim Hunter. The film received a 44% approval rating on Rotten Tomatoes.