Vince Vaughn first appeared in the Episode: "The Unquiet Earth" of the American dramatic television series ‘China Beach’ in 1989. He went on to make his silver screen debut in the 1991 American musical comedy-drama film ‘For the Boys’ where he made an uncredited appearance as a cheering soldier in the crowd. In 1993, he starred as ‘Jamie O'Hara’ in the American biographical sports film ‘Rudy’ directed by David Anspaugh. The film earned praise from critics and grossed over $22.8 million on a $12 million budget. It was also named one of the most inspiring films of all time by the American Film Institute. He next starred in films like ‘At Risk’ (1994), ‘Just Your Luck’ (1996), and ‘Swingers’ (1996). He portrayed Nick Van Owen in the 1997 American science fiction action film ‘The Lost World: Jurassic Park’ directed by Steven Spielberg. Despite opening to a mixed critical reception, the film emerged as a massive box office success, grossing over $618.6 million on a $73 million budget. That same year, he also appeared in the John Patrick Kelley-directed American drama film ‘The Locusts.’ The film failed to impress the critics, earning an 18% rating on Rotten Tomatoes. He next starred in films like ‘A Cool, Dry Place’ (1998), ‘Psycho’ (1998), ‘South of Heaven, West of Hell’ (2000), ‘The Prime Gig’ (2000), ‘Made’ (2001), ‘Domestic Disturbance’ (2001), ‘Old School’ (2003), ‘I Love Your Work’ (2003), ‘Starsky & Hutch’ (2004), ‘DodgeBall: A True Underdog Story’ (2004), ‘Thumbsucker’ (2005), and ‘Mr. & Mrs. Smith’ (2005).Â
In 2005, he starred as ‘Jeremy Grey’ in the American romantic sex comedy film ‘Wedding Crashers’ directed by David Dobkin. The film received positive reviews from critics and did decent business at the box office, grossing over $288.5 million on a $40 million budget. In 2006, he portrayed Gary Grobowski in the American romantic comedy-drama film ‘The Break-Up’ directed by Peyton Reed. Despite opening to a mixed reception, the film was a major commercial success and grossed over $205.7 million on a budget of $52 million. He continued to star in films like ‘Into the Wild’ (2007), ‘Fred Claus’ (2007), ‘Wild West Comedy Show’ (2008), ‘Couples Retreat’ (2009), ‘The Dilemma’ (2011), ‘Art of Conflict: The Murals of Northern Ireland’ (2012), ‘Lay the Favorite’ (2012), ‘The Internship’ (2013), ‘A Case of You’ (2013), ‘Unfinished Business’ (2015), ‘Hacksaw Ridge’ (2016), ‘Brawl in Cell Block 99’ (2017), ‘Dragged Across Concrete’ (2018), ‘Fighting with My Family’ (2019), ‘Seberg’ (2019), ‘Arkansas’ (2020), and ‘Freaky’ (2020).
In 2020, he joined the cast of the American television sitcom ‘Curb Your Enthusiasm’ created by Larry David. The series was renewed for another season in 2022. He was last seen in the 2021 American comedy film ‘Queenpins’ directed by Aron Gaudet and Gita Pullapilly. The film received mixed reviews from critics and was a commercial disappointment.