Anne Heche made her screen debut in the American television soap opera ‘Another World,’ in 1987. She played the role of ‘Vicky Hudson/Marley Love’ and remained a part of the show until 1991. Heche also won the ‘Daytime Emmy Award’ along with 2 ‘Soap Opera Digest Awards’ for her performance in the show. She next appeared in television films and shows such as ‘Murphy Brown’ (1991), ‘O Pioneers!’ (1992), and ‘The Young Indiana Jones Chronicles’ (1993). Heche went on to make her silver screen debut in the 1993 drama film ‘An Ambush of Ghosts,’ directed by Everett Lewis. That same year, she also portrayed ‘Mary Jane Wilks’ in the Stephen Sommers-directed American comedy-drama adventure film ‘The Adventures of Huck Finn.’ The film received mostly positive reviews from critics and was a commercial success, grossing over $24.1 million on a $6.5 million budget. She was next seen in films like ‘I'll Do Anything’ (1994), ‘Milk Money’ (1994), ‘Wild Side’ (1995), ‘The Juror’ (1996), ‘Pie in the Sky’ (1996), ‘Walking and Talking’ (1996), and ‘Donnie Brasco’ (1997). In 1997, she starred as ‘Melissa "Missy" Egan’ in the American slasher film ‘I Know What You Did Last Summer’ directed by Jim Gillespie. The film, despite receiving mixed reviews from critics, managed to come out as a major box office success and grossed over $125.3 million on a budget of $17 million. The same year, Heche also appeared in the Barry Levinson-directed American political satire black comedy film ‘Wag the Dog.’ The film garnered praise from critics and grossed over $64.3 million on a $15 million budget.
Heche received the ‘Blockbuster Entertainment Award’ nomination for her performance as ‘Robin Monroe’ in the 1998 American action-adventure comedy film ‘Six Days, Seven Nights,’ directed by Ivan Reitman. The film received a mixed response from critics but managed to come out as a commercial success and grossed over $164.8 million at the box office. The same year, she appeared in the Gus Van Sant-directed American psychological horror film ‘Psycho’ where Heche portrayed ‘Marion Crane.’ The film received a lukewarm response from critics and failed to perform at the box office. Nevertheless, Heche received ‘Saturn Award’ and ‘Fangoria Chainsaw Award’ nominations for her portrayal of Marion Crane in the film. She next starred in films such as ‘The Third Miracle’ (1999), ‘Auggie Rose’ (2000), ‘Prozac Nation’ (2001), ‘John Q.’ (2002), and ‘Birth’ (2004). In 2004, she played the role of ‘Rowena Lawson’ in the American drama film ‘Gracie's Choice’ directed by Peter Werner. The film received a positive response from critics and Heche earned an ‘Emmy Award’ nomination for ‘Outstanding Supporting Actress in a Miniseries or a Movie.’
She was next seen in television series like ‘Everwood’ (2004-2005), ‘Nip/Tuck’ (2005), ‘Higglytown Heroes’ (2005-2006), ‘Men in Trees’ (2006-2008), ‘Masters of Science Fiction’ (2007), ‘Hung’ (2009-2011), ‘Save Me’ (2013), ‘Adventure Time’ (2013-2015), ‘The Legend of Korra’ (2014), ‘Dig’ (2015), ‘Quantico’ (2015), and ‘Aftermath’ (2016). In 2017, she joined the lead cast of the American military action-drama series ‘The Brave’ as ‘DIA Dep. Director Patricia Campbell.’ The series was canceled after one season in 2018. She next starred in films such as ‘The Best of Enemies’ (2019), ‘The Vanished’ (2020), and ‘13 Minutes’ (2021). In 2021, Heche became a part of the American legal drama television series ‘All Rise’ developed by Greg Spottiswood. She played the role of ‘Corrine Cuthbert’ and remained a part of the show until 2022.
