Taraji P. Henson first appeared in the Episode: "Fast Cash" of the American sitcom television series ‘The Parent 'Hood’ in 1997. In 1998, she made her big-screen debut in the hood-action-crime thriller film ‘Streetwise’ where she played the role of ‘Tammy.’ In 2000, she appeared in the American live-action/animated adventure slapstick comedy film ‘The Adventures of Rocky and Bullwinkle’ directed by Des McAnuff. The film opened to a mixed reception and was a box office bomb. She next appeared in films like ‘Baby Boy’ (2001), ‘Book of Love: The Definitive Reason Why Men Are Dogs’ (2002), ‘Hair Show’ (2004), ‘Hustle & Flow’ (2005), ‘Animal’ (2005), ‘Something New’ (2006), and ‘Talk to Me’ (2007). In 2008, she portrayed ‘Queenie’ in the American fantasy romantic drama film ‘The Curious Case of Benjamin Button’ directed by David Fincher. The film received positive reviews from critics and received 13 Academy Award nominations including Best Supporting Actress for Henson. It was also a commercial success, grossing over $335.8 million on a budget of $150–167 million. The following year, she starred in the Bill Duke-directed American romantic comedy-drama film ‘Not Easily Broken.’ The film received mostly mixed reviews from critics.
She continued to star in films like ‘The Karate Kid’ (2010), ‘Once Fallen’ (2010), ‘The Good Doctor’ (2011), ‘Larry Crowne’ (2011), ‘Think Like a Man’ (2012), ‘Think Like a Man Too’ (2014), ‘Term Life’ (2016), ‘Hidden Figures’ (2016), ‘Proud Mary’ (2018), ‘Ralph Breaks the Internet’ (2018), and ‘Coffee & Kareem’ (2020). She was last seen in the 2021 American documentary film ‘Mary J. Blige's My Life’ directed by Vanessa Roth. The film received mixed reviews from critics and earned a 60% approval rating on Rotten Tomatoes. She will be next seen in the upcoming American computer-animated comedy film ‘Minions: The Rise of Gru’ directed by Kyle Balda.