Jim Parsons first appeared in the Episode: "The Road" of the American comedy-drama television series ‘Ed’ in 2002. The following year, he made his big-screen debut in the French film ‘Happy End’ directed by Amos Kollek. In 2004, he starred as ‘Tim’ in the American romantic comedy-drama film ‘Garden State’ directed by Zach Braff. The film was well-received at the box office and was a major commercial success, grossing over $35.8 million on a budget of $2.5 million. He next appeared in films like ‘Heights’ (2005), ‘The Great New Wonderful’ (2005), ‘10 Items or Less’ (2006), ‘School for Scoundrels’ (2006), ‘On the Road with Judas’ (2007), and ‘Gardener of Eden’ (2007). In 2007, he starred as ‘Sheldon Cooper’ in the American television sitcom series ‘The Big Bang Theory’ created by Chuck Lorre and Bill Prady. The series spawned 12 seasons before going off-air in 2019. Parsons also received several awards including 2 ‘Primetime Emmy Awards’ along with a ‘Golden Globe’ for his performance in the series. He continued to appear in television series and shows such as ‘Family Guy’ (2009, 2012), ‘Glenn Martin, DDS’ (2010), ‘The Super Hero Squad Show’ (2011), ‘Pound Puppies’ (2011), ‘iCarly’ (2011), ‘Eureka’ (2011), ‘The High Fructose Adventures of Annoying Orange’ (2012), ‘Kick Buttowski: Suburban Daredevil’ (2012), and ‘Who Do You Think You Are?’ (2013).
In 2014, he voiced ‘Oh’ in the American computer-animated science-fiction comedy film ‘Home’ directed by Tim Johnson. The film opened to a mixed reception and grossed over $386 million on a budget of $135 million. The following year, he played the role of ‘Paul Stafford’ in the American biographical drama film ‘Hidden Figures’ directed by Theodore Melfi. The film was widely praised by critics and did decent business at the box office, grossing over $236.2 million on a $25 million budget. In 2017, he became a part of the American coming-of-age sitcom television series ‘Young Sheldon’ where he voiced the ‘Adult Sheldon Cooper.’ The fifth season of the series saw its premiere in October 2021. He will be next seen in the upcoming American biographical drama film ‘Spoiler Alert’ directed by Michael Showalter.