Paz Vega first appeared in the Spanish comedy television series ‘Menudo es mi padre’ in 1997. She went on to make her silver screen debut in the 1999 comedy-drama film ‘Zapping’ directed by Chumilla-Carbajosa. That same year, she also joined the main cast of the Spanish sitcom, ‘7 vidas’ as ‘Laura Arteagabeitia Pérez.’ The show ran for 15 seasons and aired its final episode in 2006. Vega portrayed ‘Lucía’ in the 2001 Spanish drama film ‘Lucía y el sexo’ directed by Julio Medem. The film received mostly positive reviews from critics and holds a 71% approval rating on Rotten Tomatoes. Vega also won the ‘Goya Award’ for her performance in the film. She next starred in films like ‘Hable con ella’ (2002), ‘El otro lado de la cama’ (2002), ‘Novo’ (2002), ‘Carmen’ (2003), ‘Di que sí’ (2004), ‘Spanglish’ (2004), ‘10 Items or Less’ (2006), ‘Fade to Black’ (2006), ‘Teresa, el cuerpo de Cristo’ (2007), and ‘The Human Contract’ (2008). In 2008, she starred as ‘Plaster of Paris’ in the American neo-noir superhero film ‘The Spirit’ directed by Frank Miller. The film received mostly negative reviews from critics and was a box office failure. She continued to star in films like ‘Not Forgotten’ (2009), ‘The Six Wives of Henry Lefay’ (2009), ‘Burning Palms’ (2010), ‘Angel of Evil’ (2010), ‘Cat Run’ (2011), ‘Madagascar 3: Europe's Most Wanted’ (2012), ‘I'm So Excited!’ (2013), ‘Grace of Monaco’ (2014), ‘Kill the Messenger’ (2014), ‘All Roads Lead to Rome’ (2015), and ‘La vida inmoral de la pareja ideal’ (2016).
In 2016, she became a part of the Mexican drama television series ‘La Hermandad’ created by Rosa Clemente García and Raúl Prieto. She played the role of ‘Luisa Salinas’ and remained a part of the show until it went off-air in 2017. She was next seen in films such as ‘Acts of Vengeance’ (2017), ‘The Bra’ (2018), ‘Rambo: Last Blood’ (2019), ‘Chasing Wonders’ (2020), ‘American Night’ (2021), and ‘El lodo’ (2021). She was last seen in the 2022 Mexican-American action thriller film ‘There Are No Saints’ directed by Alfonso Pineda Ulloa. The film has a 31% approval rating on Rotten Tomatoes.