Talulah Riley made her acting debut in the Episode: "Five Little Pigs" of the British mystery drama television series 'Poirot' in 2003. She made her film debut in the 2005 romantic drama film ‘Pride & Prejudice,’ directed by Joe Wright. The film was based on Jane Austen's 1813 novel of the same name. The movie opened to positive reviews from critics and was a massive success at the box office.
In 2007, she starred as ‘Annabelle Fritton’ in the British comedy film 'St Trinian's.' While the film received a lukewarm response from critics, it managed to come out as a box office hit. That same year, she grabbed a lead role in the television drama mini-series 'Nearly Famous.' In 2009, Riley reprised her role as ‘Annabelle Fritton’ in 'St. Trinian's 2: The Legend of Fritton's Gold,' the sequel to the 2007 film 'St Trinian's.' The following year, she played a brief role in the Christopher Nolan-directed science fiction action film 'Inception.' The film received universal acclaim upon release and was the fourth-highest-grossing film of 2010.
She went on to appear in films like ‘Love & Distrust’ (2010), 'The Dilemma' (2011), 'White Frog' (2012), 'The Liability' (2013), ‘Thor: The Dark World’ (2013), 'The Bad Education Movie' (2015) and 'Submerged' (2016). In 2020, Riley starred as ‘Gina DeCarlo’ in the American superhero film ‘Bloodshot.’ The film opened to mixed reviews from critics with Odie Henderson of RogerEbert.com calling it a "Universal Soldier rip-off."
Talulah Riley was last seen in the 2021 British Christmas comedy film ‘Father Christmas Is Back’ directed by Philippe Martinez and Mick Davis. She is all set to appear in the upcoming biographical drama miniseries ‘Pistol,’ in which she will portray the English fashion designer and businesswoman ‘Vivienne Westwood.’