Rene Russo made her acting debut in the American mystery crime drama television series ‘Sable’ in 1987. She played the role of ‘Eden Kendell’ and remained a part of the series until it went off-air in 1988. She went on to make her big-screen debut in the 1989 American sports comedy film ‘Major League’ directed by David S. Ward. The film received positive reviews from critics and was a commercial success, grossing over $75 million on a budget of $11 million. The following year, she starred as ‘Cindy Jo Bumpers/Burrows’ in the James Orr-directed American fantasy comedy film ‘Mr. Destiny.’ The film received a lukewarm response from critics. She played the role of ‘Rita Lewis’ in the 1991 American crime drama film ‘One Good Cop’ directed by Heywood Gould. The film received mixed reviews from critics. In 1992, she starred as ‘Lorna Cole’ in the Richard Donner-directed American buddy cop action film ‘Lethal Weapon 3.’ The film saw mixed to positive reviews upon release and was a major commercial success. Russo next starred in films like ‘In the Line of Fire’ (1993), ‘Major League II’ (1994), ‘Outbreak’ (1995), ‘Get Shorty’ (1995), ‘Tin Cup’ (1996), ‘Buddy’ (1997), ‘Lethal Weapon 4’ (1998), ‘The Thomas Crown Affair’ (1999), ‘The Adventures of Rocky and Bullwinkle’ (2000), ‘Showtime’ (2002), ‘Two for the Money’ (2005), and ‘Yours, Mine & Ours’ (2005).
In 2011, she portrayed ‘Frigga’ in the American superhero film ‘Thor’ directed by Kenneth Branagh. The film received mixed to positive reviews from critics and was a major box office hit, grossing over $449.3 million on a budget of $150 million. In 2013, Russo reprised her role as ‘Frigga’ in the American superhero film ‘Thor: The Dark World.’ The film was a direct sequel to the 2011 film ‘Thor’ and was a commercial success despite opening to mixed reviews. She next starred as ‘Nina Romina’ in the 2014 American neo-noir psychological thriller film ‘Nightcrawler’ directed by Dan Gilroy. The film opened to critical acclaim and grossed over $50.3 million on a budget of $8.5 million. Russo also received the ‘AARP Award,’ ‘San Diego Film Critics Society Award,’ and ‘Saturn Award’ for her performance in the film. She next appeared in films like ‘Frank and Cindy’ (2015), ‘The Intern’ (2015), ‘Just Getting Started’ (2017), and ‘Velvet Buzzsaw’ (2019). She was last seen in the 2019 American superhero film ‘Avengers: Endgame’ where she reprised her role as ‘Frigga.’ The film earned praise from all across and was a phenomenal box office success, becoming one of the highest-grossing films of all time.