Patton Oswalt was first seen in Episode: "The Couch" of the American television sitcom ‘Seinfeld’ in 1994. He went on to make his big-screen debut in the 1996 American military comedy submarine film ‘Down Periscope’ directed by David S. Ward. The film received mostly negative reviews from critics and has an approval score of 11% on Rotten Tomatoes. In 1998, he joined the cast of the American television sitcom ‘The King of Queens’ where he played the role of ‘Spence Olchin.’ The series aired 207 episodes in a span of 6 seasons before going off-air in 2007. Oswalt continued to appear in television series and shows such as ‘Batman Beyond’ (2000), ‘Static Shock’ (2000-2004), ‘Crank Yankers’ (2002-2003), ‘Aqua Teen Hunger Force’ (2003-2006), ‘Kim Possible’ (2003-2007), ‘Reno 911!’ (2004-2020), ‘Cheap Seats: Without Ron Parker’ (2005), ‘Squidbillies’ (2006), ‘The Batman’ (2006-2007), ‘American Dad!’ (2007-2021), ‘WordGirl’ (2007-2015), ‘Community’ (2009-2010), ‘United States of Tara’ (2009-2011), and ‘Neighbors from Hell’ (2010). In 2010, he became a part of the American animated television series ‘Robotomy’ created by Michael Buckley and Joe Deasy. He voiced ‘Thrasher’ and remained a part of the show until it went off-air in 2011. He was next seen in television series such as ‘The High Fructose Adventures of Annoying Orange’ (2012), ‘Metalocalypse’ (2012), ‘Two and a Half Men’ (2012-2013), ‘Portlandia’ (2013), and ‘Axe Cop’ (2013-2015).
In 2013, he joined the voice cast of the American period sitcom television series ‘The Goldbergs’ where he grabbed the voice role of ‘Adam F. Goldberg (adult).’ The series was renewed for a tenth season in April 2022. He went on to appear in television shows like ‘Doc McStuffins’ (2014-2017), ‘Drunk History’ (2014-2016), ‘Agents of S.H.I.E.L.D.’ (2014-2020), ‘Pickle and Peanut’ (2015-2018), ‘Veep’ (2015-2019), ‘We Bare Bears’ (2015-2019), ‘Archer’ (2016), ‘Those Who Can't’ (2016-2019), and ‘Crazy Ex-Girlfriend’ (2017-2018), ‘Mystery Science Theater 3000’ (2017-present). In 2017, he joined the cast of American live-action/adult animated black comedy/action-drama television series ‘Happy!’ He voiced ‘Happy’ and remained a part of the show until it went off-air in 2019. He next appeared in television shows like ‘Robot Chicken’ (2018), ‘Big Hero 6: The Series’ (2018-2021), ‘A.P. Bio’ (2018-2021), ‘Veronica Mars’ (2019), ‘Will & Grace’ (2019-2020), ‘Mapleworth Murders’ (2020), ‘The Conners’ (2021), ‘The Ghost and Molly McGee’ (2021), and ‘Star Trek: Picard’ (2022). He was last portrayed ‘Charles Colson’ in the American political thriller television limited series ‘Gaslit’ in 2022.