Olivia Wilde made her debut in the American serial drama television series āSkinā in 2003. She played the role of āJewel Goldmanā and remained a part of the show until 2004. She went on to make her big-screen debut in the 2004 American romantic comedy film āThe Girl Next Doorā directed by Luke Greenfield. The film generated a mixed response from critics and scored a 56% approval rating on Rotten Tomatoes. Following her debut, she went on to star in films like āConversations with Other Womenā (2005), āAlpha Dogā (2006), āBickford Shmeckler's Cool Ideasā (2006), āTuristasā (2006), and āThe Death and Life of Bobby Zā (2007). In 2007, he joined the main cast of the American medical drama television series āHouseā created by David Shore. She portrayed āRemy "Thirteen" Hadleyā and remained a part of the series until 2012. In 2009, she starred as āPrincess Inannaā in the American adventure comedy film āYear Oneā directed by Harold Ramis. The film was largely panned by critics, earning a 14% approval score on Rotten Tomatoes. The following year, she appeared in the Paul Haggis-directed American action thriller film āThe Next Three Days.ā The film saw mixed reviews upon release and grossed over $67.4 million on a $30 million budget. The same year also saw the release of the American science fiction action film āTron: Legacyā where Wilde played the role of āQuorra.ā Despite opening to mixed reviews, the film managed to come out as a commercial success and grossed over $400.1 million on a budget of $170 million.
She continued to star in films like āButterā (2011), āCowboys & Aliensā (2011), āIn Timeā (2011), āDeadfallā (2012), āPeople Like Usā (2012), āDrinking Buddiesā (2013), āRushā (2013), āBetter Living Through Chemistryā (2014), āThe Lazarus Effectā (2015), āLove the Coopersā (2015), āBlack Dog, Red Dogā (2016), āA Vigilanteā (2018), āRichard Jewellā (2019), and āHow It Endsā (2021). She was last seen in the 2021 American supernatural comedy film āGhostbusters: Afterlifeā where she made an uncredited appearance as āGozer the Gozerian.ā The film generated a mixed response from critics but managed to gross over $204.6 million on a $75 million budget.