Christina Milian first appeared in the American television sitcom ‘Sister, Sister’ in 1996. The following year, she joined the cast of the American sitcom television series ‘Smart Guy’ where she played the role of ‘Pretty Girl / Kiki.’ The series ran for 3 seasons before going off-air in 1999. Milian made her silver screen debut in the 1999 American coming-of-age sex comedy film ‘American Pie’ directed by Paul Weitz. The film received mixed to positive reviews from critics and was a massive financial success, grossing over $235.5 million on a budget of $11 million. That same year, she also appeared in the Rick Famuyiwa-directed American coming-of-age film ‘The Wood.’ The film scored a 61% approval rating on Rotten Tomatoes and grossed over $25 million on a $6 million budget. In 2002, she became a part of the American animated action comedy-adventure television series ‘Kim Possible’ created by Bob Schooley and Mark McCorkle. The show spawned 4 seasons and aired its final episode in 2007. She also appeared in films like ‘Love Don't Cost a Thing’ (2003), ‘Torque’ (2004), ‘Man of the House’ (2005), ‘Be Cool’ (2005), ‘Pulse’ (2006), and ‘Snowglobe’ (2007).
In 2009, she played the role of ‘Keelia’ in the American romantic comedy film ‘Ghosts of Girlfriends Past’ directed by Mark Waters. The film received negative reviews from critics but managed to gross over $102.4 million on a budget of $37.5 million. In 2010, she joined the voice cast of the American adult animated sitcom ‘Family Guy’ created by Seth MacFarlane. She voiced ‘Esther’ and remained a part of the show until 2020. She was also seen in television series and shows like ‘CSI: Crime Scene Investigation’ (2011), ‘A Gifted Man’ (2012), ‘The Voice’ (2012-2013), ‘Dancing with the Stars’ (2013), ‘East Los High’ (2015), ‘Grandfathered’ (2015-2016), ‘90's House’ (2017), ‘The Oath’ (2019), ‘Soundtrack’ (2019), and ‘Eat the Book’ (2021). She was last seen in the 2021 Steven Tsuchida-directed American romantic comedy film ‘Resort to Love.’ The film received mixed reviews from critics.