Tom Waits made his big-screen debut in the 1978 American sports drama film ‘Paradise Alley’ where he played the role of “Mumbles.” The film received mostly negative reviews from critics. In 1981, he made an uncredited appearance in the American crime horror film ‘Wolfen’ directed by Michael Wadleigh. The film received mostly positive reviews by critics and earned a 75% approval rating on Rotten Tomatoes. He was next seen in the 1982 American musical romantic drama film ‘One from the Heart’ directed by Francis Ford Coppola. The film received a lukewarm response from critics and was a box office bomb. In 1983, he starred as ‘Buck Merrill’ in the American coming-of-age drama film ‘The Outsiders’ which was again directed by Francis Ford Coppola. The film received mixed to positive reviews from critics and did decent business at the box office, grossing over $33.7 million on a $10 million budget. That same year, he was also seen in the American drama film ‘Rumble Fish.’ The film was a commercial disaster despite opening to positive reviews. He next appeared in films like ‘The Stone Boy’ (1984), ‘The Cotton Club’ (1984), ‘Down by Law’ (1986), ‘Ironweed’ (1987), ‘Candy Mountain’ (1988), ‘Big Time’ (1988), ‘Cold Feet’ (1989), ‘The Two Jakes’ (1990), At Play in the Fields of the Lord’ (1991), ‘The Fisher King’ (1991), and ‘Queens Logic’ (1991).
In 1992, he portrayed R.M. Renfield in the American Gothic horror film ‘Bram Stoker's Dracula’ directed by Francis Ford Coppola. The film garnered praise from critics and was a massive commercial success, grossing over $215.9 million on a $40 million budget. The film also received 3 ‘Academy Awards’ for Best Costume Design, Best Sound Editing, and Best Makeup. He was next seen in television series and films such as ‘Short Cuts’ (1993), ‘Mystery Men’ (1999), ‘Coffee and Cigarettes’ (2003), ‘Domino’ (2005), ‘Wristcutters: A Love Story’ (2006), ‘The Imaginarium of Doctor Parnassus’ (2009), ‘The Book of Eli’ (2010), ‘Twixt’ (2011), ‘Seven Psychopaths’ (2012), ‘The Simpsons’ (2013), ‘The Ballad of Buster Scruggs’ (2018), ‘The Dead Don't Die’ (2019), and ‘Ultra City Smiths’ (2021). He was last seen in the 2021 American coming-of-age comedy-drama film ‘Licorice Pizza’ directed by Paul Thomas Anderson. The film opened to universal acclaim and received 5 ‘Academy Award’ and 4 ‘Golden Globe Award’ nominations.