Patricia Arquette made her screen debut as ‘Kristen Parker’ in the 1987 American fantasy slasher film ‘A Nightmare on Elm Street 3: Dream Warriors’ directed by Chuck Russell. The film received a favorable response from critics and was a commercial success, grossing over $44.8 million on a budget of $4.3–4.6 million. That same year, she also starred as ‘Zero’ in the Dimitri Logothetis-directed American comedy-drama film ‘Pretty Smart.’ The film has a 4.6 out of 10 rating on Rotten Tomatoes. She was next seen in films such as ‘Far North’ (1988), ‘Uncle Buck’ (1989), ‘Prayer of the Rollerboys’ (1990), ‘The Indian Runner’ (1991), ‘Inside Monkey Zetterland’ (1992), ‘Trouble Bound’ (1993), and ‘Ethan Frome’ (1993). In 1993, she portrayed ‘Alabama Whitman’ in the American romantic crime film ‘True Romance’ directed by Tony Scott. Even though the film garnered praise from critics, it failed to perform at the box office. However, it gained a cult following in subsequent years. Arquette went on to appear in films such as ‘Holy Matrimony’ (1994), ‘Ed Wood’ (1994), ‘Beyond Rangoon’ (1995), ‘Flirting with Disaster’ (1996), ‘Infinity’ (1996), ‘Lost Highway’ (1997), ‘The Hi-Lo Country’ (1998), ‘Bringing Out the Dead’ (1999), ‘Stigmata’ (1999), ‘Little Nicky’ (2000), ‘Human Nature’ (2001), ‘The Badge’ (2002), and ‘Holes’ (2003).
In 2005, she joined the main cast of the American supernatural drama television series ‘Medium’ as ‘Allison DuBois.’ The series aired 130 episodes in a span of 7 seasons before going off-air in 2011. Arquette also won the ‘Primetime Emmy Award’ for her performance in the series. She next starred in films like ‘Fast Food Nation’ (2006), ‘A Single Woman’ (2008), ‘Girl in Progress’ (2012), ‘A Glimpse Inside the Mind of Charles Swan III’ (2012), ‘Vijay and I’ (2013), and ‘Electric Slide’ (2013). Arquette received an ‘Academy Award’ nomination for her portrayal of ‘Olivia Evans’ in the 2014 American epic coming-of-age drama film ‘Boyhood’ directed by Richard Linklater. The film saw universal acclaim upon release and grossed over $57.3 million on a budget of $4 million. She was next seen in television series like ‘CSI: Crime Scene Investigation’ (2014), ‘CSI: Cyber’ (2015-2016), ‘Escape at Dannemora’ (2018), and ‘The Act’ (2019). She was last seen playing the role of ‘Harmony Cobel’ in the American science fiction psychological thriller television series ‘Severance’ in 2022.