Pam Grier made her screen debut in the 1970 American satirical musical melodrama film ‘Beyond the Valley of the Dolls’ directed by Russ Meyer. The film, despite being critically panned by the critics, turned out to be a decent commercial success. Following her debut, she went on to star in films ‘The Big Doll House’ (1971), ‘Women in Cages’ (1971), ‘The Twilight People’ (1972), ‘Cool Breeze’ (1972), ‘Hit Man’ (1972), ‘Black Mama White Mama’ (1973), ‘Scream Blacula Scream’ (1973), ‘The Arena’ (1974), ‘Foxy Brown’ (1974), ‘Sheba, Baby’ (1975), ‘Friday Foster’ (1975), ‘Drum’ (1976), ‘Twilight of Love’ (1977), and ‘Greased Lightning’ (1977). In 1981, she starred as ‘Charlotte’ in the American crime drama film ‘Fort Apache, The Bronx’ directed by Daniel Petrie. While the film failed to impress the critics, it managed to come out as a financial success and grossed over $65.2 million on a $10 million budget. She was next seen in films like ‘Tough Enough’ (1983), ‘Something Wicked This Way Comes’ (1983), ‘Stand Alone’ (1985), ‘The Vindicator’ (1986), ‘On the Edge’ (1986), ‘The Allnighter’ (1987), ‘Above the Law’ (1988), ‘The Package’ (1989), ‘Class of 1999’ (1990), ‘Bill & Ted's Bogus Journey’ (1991), ‘Posse’ (1993), ‘Original Gangstas’ (1996), ‘Mars Attacks!’ (1996), and ‘Fakin' da Funk’ (1997).
Grier portrayed ‘Jackie Brown’ in the 1997 American crime film ‘Jackie Brown’ directed by Quentin Tarantino. The film received a positive response from critics and grossed over $74.7 million on a budget of $12 million. Grier also won the ‘San Diego Film Critics Society Award’ and ‘Csapnivalo Award,’ and the ‘20/20 Award’ for her performance in the film. She continued to appear in films like ‘Jawbreaker’ (1999), ‘Holy Smoke!’ (1999), ‘Snow Day’ (2000), ‘Fortress 2: Re-Entry’ (2000), ‘3 A.M.’ (2001), ‘Ghosts of Mars’ (2001), ‘The Adventures of Pluto Nash’ (2002), ‘Back in the Day’ (2005), ‘Just Wright’ (2010), ‘Larry Crowne’ (2011), ‘Corman's World: Exploits of a Hollywood Rebel’ (2011), ‘Woman Thou Art Loosed: On the 7th Day’ (2012), ‘The Man with the Iron Fists’ (2012), ‘Bad Grandmas’ (2017), and ‘Being Rose’ (2017). In 2019, she starred as ‘Olive’ in the American comedy film ‘Poms’ directed by Zara Hayes. The film received a lukewarm response from critics and holds a 36% approval rating on Rotten Tomatoes. That same year, she also joined the main cast of the American single-camera sitcom ‘Bless This Mess’ created by Lake Bell and Elizabeth Meriwether. She played the role of ‘Constance Terry’ and remained a part of the show until it went off-air in 2020.