Thandie Newton made her debut in the 1991 Australian coming-of-age comedy-drama film ‘Flirting’ where she played the role of ‘Thandiwe Adjewa.’ The film received greatly positive reviews from critics. Following her debut, she went on to star in films like ‘The Young Americans’ (1993), ‘Interview with the Vampire’ (1994), ‘Jefferson in Paris’ (1995), ‘The Journey of August King’ (1995), ‘The Leading Man’ (1996), ‘Gridlock'd’ (1997), ‘Besieged’ (1998), and ‘Beloved’ (1998). In 2000, she portrayed Nyah Nordoff-Hall in the action spy film, ‘Mission: Impossible 2’ directed by John Woo. The film garnered mixed to positive reviews and was a major box office success, grossing over $546.4 million on a budget of $125 million. Newton also received the ‘Empire Award,’ ‘NAACP Image Award,’ and ‘Blockbuster Entertainment Award’ nominations for her performance in the film. She went on to receive another ‘NAACP Image Award’ nomination along with a ‘Black Reel Award’ nomination for her performance as ‘Regina Lambert’ in the 2002 mystery film ‘The Truth About Charlie’ directed by Jonathan Demme. The film, however, was poorly received by critics and was a box office flop. In 2003, she appeared in the Damian Nieman-directed American neo-noir crime thriller film, ‘Shade.’ The film received positive to mixed reviews from critics.
The year 2004 saw the release of the crime drama film ‘Crash’ where she portrayed Christine Thayer. The film opened to a positive reception and was a major commercial success, grossing over $98.4 million on a budget of $6.5 million. Newton also bagged the ‘BAFTA Award,’ ‘Empire Award,’ and ‘London Film Critics Circle Award’ for her performance in the film. She next starred in films like ‘The Pursuit of Happyness’ (2006), ‘Norbit’ (2007), ‘Run Fatboy Run’ (2007), ‘RocknRolla’ (2008), ‘How to Lose Friends & Alienate People’ (2008), ‘2012’ (2009), ‘For Colored Girls’ (2010), ‘Retreat’ (2011), ‘Good Deeds’ (2012), and ‘Half of a Yellow Sun’ (2013). In 2016, she joined the cast of the American dystopian science fiction neo-Western television series ‘Westworld’ created by Jonathan Nolan and Lisa Joy. The series was renewed for a fourth season which is expected to release in 2022. Newton next starred in films like ‘Gringo’ (2018), ‘Solo: A Star Wars Story’ (2018), and ‘Reminiscence’ (2021). She was last seen in the 2022 American spy thriller film ‘All the Old Knives’ directed by Janus Metz Pedersen. The film received mostly positive reviews from critics.