Mira Sorvino made her screen debut in the 1985 Larry Cohen-directed American satirical science fiction horror film ‘The Stuff’ where she made an uncredited appearance as a factory worker. The film holds a 71% approval rating on Rotten Tomatoes. She was next seen in films like ‘Amongst Friends’ (1993), ‘New York Cop’ (1993), ‘Quiz Show’ (1994), ‘Barcelona’ (1994), and ‘Sweet Nothing’ (1995). In 1995, she played the role of ‘Linda Ash’ American comedy film ‘Mighty Aphrodite’ directed by Woody Allen. The film received mostly positive reviews from critics with praise mostly directed towards the performance of Sorvino. She also won the ‘Academy Award’ and the ‘Golden Globe Award’ for her portrayal of ‘Linda Ash’ in the film. That same year, she also appeared in the American comedy film ‘Blue in the Face’ directed by Paul Auster and Wayne Wang. The film opened to a mixed reception and has a 43% approval rating on Rotten Tomatoes. She next starred in films like ‘Beautiful Girls’ (1996), ‘Tarantella’ (1996), ‘Romy and Michele's High School Reunion’ (1997), ‘Mimic’ (1997), ‘The Replacement Killers’ (1998), ‘Summer of Sam’ (1999), ‘The Grey Zone’ (2001), ‘WiseGirls’ (2002), ‘Between Strangers’ (2002), ‘Gods and Generals’ (2003), and ‘The Final Cut’ (2004). In 2005, she starred as ‘Kate Morozov’ in the television miniseries, ‘Human Trafficking.’ Sorvino received a Golden Globe Award nomination for her performance in the show.
She portrayed ‘Ruth’ in the 2007 American crime drama film ‘Reservation Road’ directed by Terry George. The film generated a mixed response from critics and sits on a 38% approval score on Rotten Tomatoes. She continued to star in films like ‘Like Dandelion Dust’ (2009), ‘Attack on Leningrad’ (2009), ‘Multiple Sarcasms’ (2010), ‘Angels Crest’ (2011), ‘Union Square’ (2012), ‘Space Warriors’ (2013), ‘Quitters’ (2015), ‘Do You Believe?’ (2015), ‘Exposed’ (2016), ‘6 Below: Miracle on the Mountain’ (2017), ‘Waterlily Jaguar’ (2018), ‘Beneath the Leaves’ (2019), ‘Stuber’ (2019), ‘Butter’ (2020), ‘The Girl Who Believes in Miracles’ (2021), and ‘Crime Story’ (2021). In 2021, she starred as ‘Carol’ in the American romantic drama film ‘After We Fell’ directed by Castille Landon. The film received mostly negative reviews from critics. Sorvino was last seen in the American comedy horror television series, ‘Shining Vale’ in 2022.