Priyanka Chopra made her screen debut in the 2002 Indian Tamil-language courtroom drama film ‘Thamizhan’ directed by Majith. The film was a box office success despite opening to mixed reviews. In 2003, she made her Bollywood debut in the Anil Sharma-directed Indian Hindi-language spy thriller film ‘The Hero: Love Story of a Spy’ where she portrayed ‘Dr. Shaheen Zakaria.’ The film earned praise from critics and while it was a commercial success, the film was considered a box office disappointment due to a high production cost. The same year, she also starred as ‘Jiyana "Jiya" Singhania’ in the Indian Hindi-language romantic musical film ‘Andaaz’ directed by Raj Kanwar. The film received a positive response from critics and was a financial success. Chopra also became a recipient of the ‘Filmfare Award’ for her performance in the film. She next starred in films like ‘Plan’ (2004), ‘Kismat’ (2004), ‘Mujhse Shaadi Karogi’ (2004), ‘Aitraaz’ (2004), ‘Karam’ (2005), ‘Waqt: The Race Against Time’ (2005), ‘Barsaat’ (2005), ‘Krrish’ (2006), ‘Don’ (2006), ‘Salaam-e-Ishq: A Tribute to Love’ (2007), ‘Love Story 2050’ (2008), and ‘God Tussi Great Ho’ (2008). She won the ‘Filmfare Award’ for her portrayal of ‘Meghna Mathur’ in the 2008 Indian Hindi-language drama film ‘Fashion’ directed by Madhur Bhandarkar. The film saw critical acclaim upon release and performed well at the box office.
She continued to star in films like ‘Kaminey’ (2009), ‘Pyaar Impossible!’ (2010), ‘Anjaana Anjaani’ (2010), ‘7 Khoon Maaf’ (2011), ‘Don 2’ (2011), ‘Agneepath’ (2012), ‘Barfi!’ (2012), ‘Planes’ (2013), ‘Krrish 3’ (2013), ‘Gunday’ (2014), ‘Mary Kom’ (2014), ‘Mary Kom’ (2014), ‘Dil Dhadakne Do’ (2015), and ‘Bajirao Mastani’ (2015). In 2015, she grabbed the role of ‘Alex Parrish’ in the American thriller drama television series, ‘Quantico.’ The series aired 57 episodes in a span of 3 seasons before going off-air in 2018. She portrayed ‘Victoria Leeds’ in the 2017 American action comedy film ‘Baywatch’ directed by Seth Gordon. The film was largely panned by critics but managed to gross over $177.9 million on a budget of $65–69 million. She was next seen in films like ‘A Kid Like Jake’ (2018), ‘Isn't It Romantic’ (2019), ‘The Sky Is Pink’ (2019), ‘We Can Be Heroes’ (2020), and ‘The White Tiger’ (2021). She was last seen in the 2021 American science fiction action film ‘The Matrix Resurrections’ directed by Lana Wachowski. While the film received mostly positive reviews from critics, it tanked at the box office.