Nnamdi Asomugha was first seen in the Episode: "The List" of the American television series ‘The Game’ in 2008. The following year, he starred as ‘Ken Shaw’ in the American sports drama television series ‘Friday Night Lights.’ He next appeared in the American action crime drama television series ‘Leverage’ (2010) before making his big-screen debut in the 2012 American action thriller film ‘Fire with Fire’ directed by David Barrett. The film saw a direct-to-video release and received mostly negative reviews from critics. In 2015, he produced the American war drama film ‘Beasts of No Nation’ directed by Cary Joji Fukunaga. The film saw greatly positive reviews upon release. The following year, he starred as ‘Shaka’ in the American coming-of-age romantic comedy-drama film ‘Hello, My Name Is Doris’ directed by Michael Showalter. The film earned praise from critics and was a major commercial success, grossing over $14.7 million on a budget of $1 million.
In 2017, Asomugha was seen playing the role of ‘Carl King’ in the American biographical crime drama film ‘Crown Heights’ directed by Matt Ruskin. The film saw its premiere at the Sundance Film Festival where it received positive reviews. He was last seen in the 2020 American romantic drama film ‘Sylvie's Love’ directed by Eugene Ashe. The film received a positive response from critics. He is all set to appear in the upcoming American crime thriller film ‘The Good Nurse’ directed by Tobias Lindholm.