Luke Perry first appeared in Episode: "The Day the Rebs Took Lincoln" of the American science fiction television series ‘Voyagers!’ in 1982. After appearing in television shows like ‘Loving’ (1988) and ‘Another World’ (1988-1989), he grabbed the role of ‘Dylan McKay’ in the American teen drama television series ‘Beverly Hills, 90210’ in 1990. He remained a part of the show until 1995 but made a return in 1998 and continued to appear in the series until it went off-air in 2000. Perry made his silver screen debut in the 1991 drama film ‘Scorchers’ directed by David Beaird. Following his debut, he went on to star in films like ‘Terminal Bliss’ (1992), ‘Buffy the Vampire Slayer’ (1992), ‘8 Seconds’ (1994), ‘Vacanze di Natale '95’ (1995), ‘Normal Life’ (1996), and ‘American Strays’ (1996). In 1997, he starred as ‘Billy Masterson’ in the English-language French science fiction action film ‘The Fifth Element’ directed by Luc Besson. While the film opened to polarizing reviews, it still managed to gross over $263.9 million on a $90 million budget.
He next starred in films like ‘Indiscreet’ (1998), ‘The Heist’ (1999), ‘The Florentine’ (1999), ‘Attention Shoppers’ (2000), ‘The Enemy’ (2001), ‘Dirt’ (2001), ‘Fogbound’ (2002), ‘Dishdogz’ (2005), ‘Alice Upside Down’ (2007), ‘Äntligen midsommar!’ (2009), ‘Redemption Road’ (2010), ‘Good Intentions’ (2010), ‘Red Wing’ (2013), and ‘The Griddle House’ (2018). He was last seen in the 2019 comedy-drama film ‘Once Upon a Time in Hollywood’ directed by Quentin Tarantino. The film earned praise from critics and was a box office success, grossing over $374.6 million on a budget of $90–96 million.