Paul O'Grady first appeared in the television talk show ‘The Last Resort with Jonathan Ross’ in 1988. That same year, he also joined the cast of the British police procedural television series ‘The Bill,’ created by Geoff McQueen. He played the role of ‘Roxanne’ and remained a part of the show until 1990. In 1991, he portrayed ‘Donaldson’ in the British science-fiction horror drama television series ‘Chimera,’ directed by Lawrence Gordon Clark. The series holds a 6.3 out of 10 rating on IMDb. The following year, he starred as ‘Marlene Dietrich’ in the Episode: “Heil and Farewell” of the British sitcom ‘The New Statesman.’ O'Grady made his big-screen debut in the 1993 biographical crime drama film ‘In the Name of the Father,’ directed by Jim Sheridan. The film opened to massive acclaim and received 7 ‘Academy Award’ nominations, including ‘Best Director’ and ‘Best Picture.’ It was also a major commercial success and grossed over $65.8 million on a budget of $13 million. He was next seen in television shows like ‘Top of the Pops’ (1994), ‘The Big Breakfast’ (1995-1996), ‘An Evening with Lily Savage’ (1996), and ‘The Lily Savage Show’ (1997). In 1997, he became a part of the British comedy game show ‘Blankety Blank’ as a presenter. He hosted 56 episodes and parted ways from the show in 2002.
He continued to appear in television series and shows such as ‘Love Bites with Lily Savage’ (1999), ‘Paul O'Grady's Orient’ (2000), ‘Lily Live!’ (2000-2001), ‘Paul O'Grady's America’ (2001), ‘Outtake TV’ (2002-2003), ‘Today with Des and Mel’ (2003), and ‘Eyes Down’ (2003-2004). In 2004, he joined the British comedy chat show ‘The Paul O'Grady Show’ as a presenter. The show ran for 15 seasons and aired its final episode in 2015. O'Grady next starred in television shows such as ‘Comic Aid’ (2005), ‘Doctor Who’ (2008), ‘Coronation Street: The Big 50’ (2010), ‘Paul O'Grady Live’ (2010-2011), ‘Paul O'Grady: For the Love of Dogs’ (2012-2021), ‘The One and Only Des O'Connor’ (2012), ‘Paul O'Grady's Working Britain’ (2013), ‘Holby City’ (2013), ‘Paul O'Grady's Animal Orphans’ (2014-2016), ‘Bob Monkhouse: The Million Joke Man’ (2015), and ‘Paul O'Grady's Favourite Fairy Tales’ (2016). In 2017, he became a part of the British dating game show ‘Blind Date.’ The show ran for 4 seasons before going off-air in 2019. O'Grady was last seen playing the role of ‘David’ in the crime-drama television series ‘The Madame Blanc Mysteries’ in 2021.