Jack Griffo made his debut in the 2011 American psychological thriller film ‘Sound of My Voice’ directed by Zal Batmanglij. The film saw its premiere at the Sundance Film Festival and received mostly positive reviews upon release. That same year, he also appeared in the American comedy television series ‘Kickin' It.’ He next appeared in television series like ‘Bucket and Skinner's Epic Adventures’ (2011), ‘Marvin Marvin’ (2013), ‘Jessie’ (2013), and ‘See Dad Run’ (2013). In 2013, he joined the main cast of the American comedy television series ‘The Thundermans’ where he played the role of ‘Max Thunderman.’ The show ran for 4 seasons and aired its final episode in 2018. Griffo also received 4 ‘Kids' Choice Award’ nominations for his performance in the series. In 2015, he starred as ‘Billy’ in the American made-for-television action comedy horror film ‘Sharknado 3: Oh Hell No!’ directed by Anthony C. Ferrante. The film received a mixed response from critics.
Griffo continued to appear in television series and shows like ‘NCIS: Los Angeles’ (2016), ‘Henry Danger’ (2016), ‘Paradise Run’ (2016-2017), and ‘The Dude Perfect Show’ (2017). In 2018, he became a part of the American sitcom ‘Alexa & Katie’ created by Heather Wordham. He played the role of ‘Dylan’ and remained on the show until 2019. He next appeared in television series and shows such as ‘Lip Sync Battle Shorties’ (2018), ‘The Loud House’ (2018, 2021), ‘School of Rock’ (2018), ‘Best.Worst.Weekend.Ever.’ (2018), ‘Knight Squad’ (2018), ‘SpongeBob SquarePants’ (2019), ‘SEAL Team’ (2020), and ‘The Christmas High Note’ (2020). The year 2020 saw the release of the American action film ‘The 2nd’ where Griffo was seen playing the role of ‘Shawn Davis.’ The film saw negative reviews upon release. He is all set to appear in the upcoming coming-of-age comedy ‘Sid Is Dead’ directed by Eli Gonda.