Nadine Velazquez made her silver screen debut in the 2003 American sports action drama film ‘Biker Boyz’ directed by Reggie Rock Bythewood. The film was panned by critics and was a commercial failure. She next starred in films like ‘Chasing Papi’ (2003), ‘The Last Ride’ (2004), ‘Blast’ (2004), ‘Hollywood Vice’ (2005), ‘Sueño’ (2005), and ‘House of the Dead 2’ (2005). In 2005, she joined the main cast of the American television sitcom ‘My Name Is Earl’ as ‘Catalina.’ The series was canceled after 4 seasons in 2009. She continued to star in television series and shows such as ‘CSI: NY’ (2009), ‘Gary Unmarried’ (2009), ‘The League’ (2009-2015), ‘Scrubs’ (2010), ‘CSI: Miami’ (2010), ‘Hawaii Five-0’ (2010), ‘Charlie's Angels’ (2011), and ‘Hart of Dixie’ (2011-2012). In 2012, she starred as ‘Katerina Marquez’ in the Robert Zemeckis-directed American drama film ‘Flight.’ The film opened to a positive reception and grossed over $161.8 million on a $31 million budget. The following year, she grabbed the role of ‘Deputy District Attorney Emma Rios’ in the American police procedural television series ‘Major Crimes’ created by James Duff. She parted ways from the series in 2017. She next starred in television series such as ‘Killer Women’ (2014), ‘The Exes’ (2014), ‘Z Nation’ (2016), ‘Six’ (2017-2018), and ‘The Guest Book’ (2018). In 2021, she became a part of the American musical drama television series ‘Queens’ as ‘Valeria "Butter Pecan" Mendez.’ The series was canceled after one season in 2022.