Alessandra Mussolini made her screen debut in the 1972 Italian comedy film ‘Bianco, rosso e…’ directed by Alberto Lattuada. The film did well at the box office. In 1977, she portrayed ‘Maria Luisa’ in the Italian drama film ‘A Special Day’ directed by Ettore Scola. The film opened to a positive critical reception and received an ‘Academy Award’ nomination for ‘Best Foreign Language Film.’ She was next seen in films like ‘Il Caso Pupetta Maresca’ (1982), ‘Il Tassinaro’ (1983), and ‘Qualcosa di biondo’ (1984). In 1985, she played the role of ‘Sister Beata’ in the American film ‘The Assisi Underground’ directed by Alexander Ramati. The film received a lukewarm response from critics. The following year, she starred as ‘Fotomodella’ in the television miniseries, ‘Mid-August OK.’ The series was directed by Sergio Martino. She next portrayed ‘Adua’ in the 1987 Italian comedy film ‘Noi uomini duri’ directed by Maurizio Ponzi. The film received positive reviews from critics. In 1988, she played the role of ‘Fiamma’ in the Italian television film ‘Vincere per vincere’ directed by Stefania Casini. She next appeared in the 1990 comedy film ‘Sabato, domenica e lunedì’ directed by Lina Wertmüller. Mussolini was last seen in the 1990 Doron Eran-directed Israeli film ‘HaDerekh LeEin Harod’ where she played the role of ‘Liora.’