Sarah Greene was first seen in the Irish (RTÉ) comedy-drama series ‘Bachelors Walk’ in 2006. She made her big-screen debut in the 2008 drama film ‘Eden’ directed by Declan Recks. The film holds a 72% approval score on Rotten Tomatoes while a 5.9 out of 10 rating on IMDb. In 2009, she starred as ‘Cathleen’ in the Canadian-Irish drama film ‘Love and Savagery’ directed by John N. Smith. The film received 4 ‘Genie Award’ nominations at the 30th ‘Genie Awards.’ She next portrayed ‘Sinead Mulligan’ in the 2011 John Michael McDonagh-directed Irish buddy cop crime comedy film ‘The Guard.’ The film garnered praise from critics upon release and grossed over $21.2 million on a budget of $6 million. In 2014, she starred in the drama film ‘Noble’ directed by Stephen Bradley. The film holds an 81% approval rating on Rotten Tomatoes. She next portrayed ‘Kaitlin’ in the 2015 American drama film ‘Burnt’ directed by John Wells. The film, despite being panned by critics, managed to gross over $36.6 million on a $20 million budget. That same year, she also joined the cast of the horror drama television series ‘Penny Dreadful’ created by John Logan. She played the role of ‘Hecate Poole’ and remained a part of the show until it went off-air in 2016.
In 2016, she starred as ‘May Lacy’ in the historical drama television serial ‘Rebellion’ created by Colin Teevan. The series was based on the events surrounding the Easter Rebellion that took place in 1916. In 2017, she joined the main cast of the drama television series ‘Ransom’ as ‘Maxine Carlson.’ She starred in 2 seasons and parted ways from the show in 2018. She next appeared in television series and films such as ‘Dublin Oldschool’ (2018), ‘Black 47’ (2018), ‘Rosie’ (2018), ‘Dublin Murders’ (2019), ‘Normal People’ (2020), and ‘Roadkill’ (2020). Greene was last seen playing the role of ‘Aine’ in the 2021 Irish comedy television series ‘Frank of Ireland’ created by Brian Gleeson, Domhnall Gleeson, and Michael Moloney.