Son Na-eun made her acting debut in the 2012 crime-comedy film ‘Marrying the Mafia 5,’ directed by Yong-ki Jeong. That same year, she also joined the cast of the South Korean television series ‘My Kids Give Me a Headache,’ directed by Kim Soo-hyun. She played the role of ‘Oh Soo-mi’ and remained a part of the show until it went off-air in 2013. Na-eun was next seen in television series like ‘Second 20s’ (2015), ‘Cinderella with Four Knights’ (2016), and ‘The Most Beautiful Goodbye’ (2017).
In 2018, she portrayed ‘Ok-boon’ in the South Korean horror mystery film ‘The Wrath,’ directed by Yoo Young-sun. The film was a remake of the 1986 horror film ‘Woman's Wail’ and grossed over US$470,685 at the box office. She next appeared in the 2020 South Korean television series ‘Dinner Mate’ where she played the role of ‘Jin No-eul.’ The show aired a total of 32 episodes. In 2021, Na-eun starred as ‘Min-jung’ in the South Korean television series ‘Lost,’ directed by Hur Jin-ho and Park Hong-soo. The series marked the television debut of director Hur Jin-ho. Na-eun was last seen playing the role of ‘Oh Su-jeong’ in the 2022 South Korean television series ‘Ghost Doctor’ directed by Boo Seong-cheol.